Showing posts with label tests for dementia. Show all posts
Showing posts with label tests for dementia. Show all posts

Sunday, July 3, 2011

10 Scoring Approaches for Alzheimer's Clock Draw Test –Alzheimer's Early Detection

Drawing a clock by hand is one of easiest to administer and one of the most popular screening tools that can help to detect mild cognitive impairment, dementia, or Alzheimer's among new patients. The test can be done anytime, anywhere, and can be self-administered as well.

There are numerous versions of the clock-drawing test. They all involve asking the patient to draw the face of a clock. Variations include providing a blank piece of paper or a paper with a pre-drawn (often 10 cm diameter) circle and asking the patient to draw the face of a clock. Further questions from the patients may be politely deferred by repeating the request to draw the face of a clock. Most variations of the test also include asking the patient to draw in the arms to denote certain time. Many times have been used including, 3:00, 3:40, 8:40, 2:45 and so on. They time 11:10 has been suggested as useful because of the distraction of "pull" of the numeral ten on the clock when setting a time. Generally there is no time limit to the test, but the test usually takes only one to two minutes.

If you administer the test to somebody else, in general, look first at symmetry of the numbers of the clock. This can indicate whether or not the patient was able to plan ahead.  Leaving numbers out, repeating numbers, or continuing past the number 12 is also an indication of abnormality. Secondly, look at the hands. Deliberately choose a time from the offered list that is not straightforward because you are looking for disinhibition or “frontal pull.”  The time ‘ten after eleven’ requires that the patient inhibit a reflex to put the hands at the numbers 10 and 11. This also requires abstract thinking to translate the concept of time into a drawing.

Test Description

  1. Draw a clock by hand on a large piece of paper (about 10 cm in diameter).
  2. Draw the face of a clock and put the numbers in the correct positions.
  3. Then draw the hands to indicate 3:40 (time).

Standard Scoring

To score, assign the following points for each part of the drawing:
  • 1 point for the clock circle.
  • 1 point for all the numbers being in the correct order.
  • 1 point for the numbers being in the proper special order.
  • 1 point for the two hands of the clock.
  • 1 point for the correct time.

Less points you get in the test, more you should worry about the potential symptoms of Alzheimer’s Disease. A normal score is four or five points out of five.

A simple similar results interpretation is offered by Stahelin:
·         The number 12 must appear on top (3 points),
·         There must be 12 numbers present (1 point),
·         There must be two distinguishable hands (1 point),
·         The time must be identified correctly (1 point) for full credit.

A score less than 4 (out of 6) is considered impaired.

Advanced Scoring

While the test itself is very easy and fast to administer or self-administer, and standard scoring process is equally easy and fast to obtain results, there are a number of variations on advanced scoring the clock, more than variations in administering the test itself. Most scoring systems are highly correlated with well-established measures including the MMSE, Dementia Rating Scale and the Global Deterioration Scale. Let’s briefly review the main advanced scoring approaches:

  1. Mendez et al. 1992. Clock Drawing Interpretation Scale (CDIS) with the time "ten minutes past eleven." Each positive result earns a score 1.
1.       There is an attempt to indicate a time in any way.
2.       All marks or items can be classified as either part of a closure figure, a hand or a symbol for clock numbers.
3.       There is a totally closed figure without gaps ("the closure figure"). Score only if symbols for clock numbers are present.
4.       A "2" is present and pointed out in some way for the time.
5.       Most symbols are distributed as a circle without major gaps.
6.       Three or more clock quadrants have one or more appropriate numbers per respective quadrant.
7.       Most symbols are ordered in a clockwise fashion.
8.       All symbols are totally within a closure figure.
9.       An "11" is present and is pointed out in some way for time.
10.   All numbers 1 to 12 are present.
11.   There are no repeated or duplicated number symbols.
12.   There are no substitutions for Arabic or Roman numerals.
13.   The numbers do not go beyond the number 12.
14.   All symbols lie about equally adjacent to a closure figure edge.
15.   Seven or more of the same symbol type are ordered sequentially. Score only if one or more hands are present.
16.   All hands radiate from the direction of a closure figure's center.
17.   One hand is visibly longer than another hand.
18.   There are two distinct and separable hands.
19.   All hands are totally within a closure figure.
20.   There is an attempt to indicate a time with one or more hands.

  1. Lam et al. 1998. Scoring criteria for clock drawing test. Chose score by description of the produced clock. Lower score you get – smaller signs of Alzheimer’s.

  • 0 - Correct time shown with normal spacing.
  • 1 - Slight impairment in spacing of lines or numbers.
  • 2 - Noticeable impairment in line spacing.
  • 3 - Incorrect spacing between numbers with subsequent inappropriate denotation of time.
  • 4 - Obvious errors in time denotation (arms misplaced, numbers in wrong place)
  • 5 - Abnormal clock-face drawing with inaccurate time denotation (e.g. reversal of numbers, perseveration beyond twelve, misplaced numbers, drawing only to one side, omitting most numbers)
  • 6 - Abnormal clock face drawing with inaccurate time denotation (e.g. reversal of numbers, perseveration beyond twelve, misplaced numbers and drawing to one side and omitting most numbers).
  • 7 - A recognizable attempt to draw a clock face but no clear denotation of time.
  • 8 - Some evidence that a clock face is drawn.
  • 9 - Minimal evidence that a clock face is drawn.
  • 10 - No reasonable attempt to drawing a clock face (exclude gross visual disturbance, hemiplegia and severe psychotics state).
 
  1. Wolf-Klein et al. 1989. Scoring criteria for clock drawing test. Chose score by description of the produced clock. Higher score you get – smaller signs of Alzheimer’s.

·         X - Normal
·         IX - almost normal except for number
·         VIII - almost normal except for spacing
·         VII - very inappropriate spacing
·         VI - perseveration
·         V - absence of numbers
·         IV  - counter clockwise rotation
·         III - other
·         II - irrelevant spatial arrangement
·         I - irrelevant figures

  1. Shua-Haim et al. 1996. Simple scoring system. Award one point for each of the following:

    • Approximate drawing of the clock face.
    • Presence of numbers in sequence.
    • Correct spacial arrangement of numbers
    • Presence of clock hands
    • Hands showing approximately the correct time
    • Hands depicting the exact time

  1. Shulman et al. 1986. Classification of clock errors with the time

1.       Visual spatial
a.       Mildly impaired spacing of times
b.      Draws lines outside of circle
c.       Turns page while writing numbers so that some numbers appear upside down
d.      Draws in lines to orient spacing.
2.       Error in denoting time as 3 o'clock
a.       Omits minute hand
b.      Draws single line from 3 to 12
c.       Writes words 3 o'clock
d.      Writes number three again
e.      Circles or underlines 3
f.        Unable to indicate 3 o'clock
3.       Visual spatial
a.       Moderately impaired spacing of lines
b.      Omits number
c.       Perseveration
                                                                     i.            Repeats circle
                                                                   ii.            Continues on past 12 to 13, 14, 15 etc
                                                                  iii.            Counter-clockwise
                                                                 iv.            Dysgraphia
4.       4. Severely disorganized spacing
a.       Confused time, writes in minutes, times of day, months or seasons
b.      Draws picture of human face
c.       Writes words "clock"
5.       Unable to make reasonable attempt at clock
a.       Exclude severe depression or psychotic state.

  1. Sunderland et al. 1983. This is one of the most popular scoring systems for evaluating clock drawings. Higher the score – better the patient mental state. This method usually involves giving patients a pre-drawn circle.

·         10-6 - Drawing of clock face with number and circle generally intact
o   10 - Hands in correct position (i.e. Hours hand approaching 3 o'clock)
o   9 - Slight errors in placement of hands.
o   8 - More noticeable errors in placement of hour and minute hands
o   7 - Placement of hands is significantly off course
o   6 - Inappropriate use of clock hands (i.e. use of digital display or circling numbers despite repeated instructions).

·         5-1 -Drawing of clock face with circle and numbers is NOT intact
o   5 - Crowding of numbers at one end of the clock or reversal of numbers. Hands may still be present in some fashion.
o   4 - Further distortion of number sequence. Integrity of clock face is now gone (i.e. numbers missing or placed outside of boundaries of the clock face)
o   3 - Numbers and clock face no longer obviously connected in the clock drawing. Hands are not present.
o   2 - Drawing reveals some evidence of instructions being received but only vague representation of a clock.
o   1 - Either no attempt or an uninterpretable effort is made.

  1. SHULMAN scoring system, 1993. Scoring criteria is presented below, while lower score gives higher warnings.
  • 0 - No reasonable representation of a clock
—No attempts at all
—No semblance of a clock at all
—Writes a word or name
  • 1- Severe level of disorganization as described in 2
  • 2 - Moderate visio-spatial disorganization of times such that accurate denotation of 10 after 11 is impossible
—Moderately poor spacing
—Omits numbers
—Perseveration—repeats circle or continues on past 12 to 13, 14, 15 etc.
—Right-left reversal—numbers drawn counterclockwise
—Dysgraphia—unable to write numbers accurately
  • 3- Inaccurate representation of 10 after 11 when visio-spatial organization is perfect or shows only minor deviations
—Minute hand points to 10
—Writes ‘10 after 11’
—Unable to make any denotation of time
  • 4 - Minor visio-spatial errors
—A mildly impaired spacing of times
—Draws times outside circle
—Turns page while writing numbers so that some numbers appear upside down
—Draws in lines (spokes) to orient spacing
  • 5 - Perfect clock

  1. Watson Scoring System. The Watson method of scoring the CDT divides the clock into four quadrants.  This technique does not score the hands, but focuses exclusively on the placement of numbers or symbols within each quadrant. 

Scoring is performed through the following approach:
  • Draw one line through the center of the circle and the number 12 or mark that best corresponds to the number 12.  Draw another line perpendicular to this line also through the middle of the circle.  This will divide the clock into four segments.
  • Moving in a clockwise fashion, count the number of digits in each quadrant beginning with the number 12.  If a digit falls on one of the quadrant lines, it is included in the quadrant preceding the line.  A total of 3 digits in one quadrant is considered correct.
  • If there is an error in numbers of digits in the first three quadrants (spanning numbers 12 through 9), assign a score of 1.  For any error in the number of digits in the last quadrant, assign a score of 4.
  • The sum of the scores for each quadrant is the total score for the clock.
  • Normal range of scores is 0 to 3. Abnormal range of scores is 4 to 7.

If you administer the test on your own and find the results either disconcerting or suspicious, schedule an appointment with your personal care physician. Take the copy of the clock test with you to the doctor appointment, and show the test to the doctor. Insist on a referral to a memory specialist for testing.

There are many diseases that can present as dementia or Alzheimer's. Getting the correct diagnosis is difficult under any and all circumstances. You need to be sure all the proper tests are administered.



Sources and Additional Information:


Thursday, March 17, 2011

Early Detection Alzheimer’s in Elderly Patients

Detecting Dementia

Making the diagnosis of dementia is reasonably straightforward in the moderate and severe stages, but it can be problematic to distinguish the early stages of Alzheimer’s from “normal” ageing in elderly patients, although recent development has helped to clarify which neuropsychological tests discriminate most effectively. Most people who present with concerns about memory problems do not in fact have dementia, and it is also important to note that in specialist clinical practice professionals see an atypical group of patients. O’Connor (1994) found that only 3% of people identified in a community survey as having mild dementia had been referred to specialist services, along with 18% of those with moderate dementia and 33% of those with severe dementia.

Image and video hosting by TinyPic

Early Detection

Interest in the early detection of Alzheimer’s has increased with the recent licensing of anti-cholinesterase inhibiting medication as a treatment for the cognitive impairment of early-stage Alzheimer’s. This detection on early-stage of the disease is increasingly undertaken in the context of multidisciplinary memory clinics, where neuropsychological assessment plays a critical role in establishing a diagnosis. Early detection of DAT offers the possibility of introducing psychosocial and pharmacological interventions at an early stage. It has been demonstrated that memory clinics can provide an effective focus for early intervention and for the development of integrated psychosocial approaches. Early detection of Alzheimer’s remains a challenge, however, and there are a number of barriers to early detection. People with dementia, and their families, may interpret certain memory impairment of the patients as part of normal ageing process or deny that there have been any changes, and rates of detection by general medical practitioners are low.

Distinguishing Dementia from “Normal” Ageing

The boundaries between dementia and normal forgetfulness still appear somewhat fluid, and it remains unclear how the difference between dementia and normal ageing should be conceptualized. Although many older people and their families expect to observe a decline in memory functioning, there is a great deal of variation in the general population as regards the kinds of memory changes seen as part of “normal” ageing, and the issue is compounded by cohort effects. A broad overview suggests that, although memory functioning becomes less efficient from about 67 years onwards there is no general decline in memory ability and no uniform decline across the range of different memory tasks. Memory functioning is relatively more affected in the very old, so that diagnostic criteria do not allow for a dementia diagnosis made after the age of 90. The following general observations can be made with regard to memory changes in healthy older people:
  • Working memory may be affected.
  • Episodic memory is affected to a much greater degree than semantic or procedural memory.
  • Immediate recall is affected more than delayed recall, while recognition memory is unaffected.
  • Retrieval is slower and less efficient, with more rapid and extensive forgetting.
  • Prospective memory remains as good as that of younger people if external aids and reminders can be used, but is poorer if no such aids are available.
  • Autobiographical memory does not show the stereotypical discrepancy between vivid memories of the distant past and hazy memories of more recent events; instead, memories across the lifespan show loss of detail and become vaguer.
  • Alterations in memory functioning can be offset by intelligence, expertise and use of compensatory strategies, enabling the person to cope well despite any changes.

Image and video hosting by TinyPic

What is “Normal” Memory Loss?

  • Forgetting people’s names occasionally;
  • sometimes not being able to find the right word;
  • taking longer to learn new things;
  • sometimes forgetting where one has put things, like keys, for example;
  • sometimes forgetting what one has come into a room to do.

What are the Symptoms of More Serious Memory Loss?

A more serious memory problem is one that affect’s a person’s ability to carry out everyday life activities such as driving a car, shopping or managing money. Some of the signs are:
  • asking the same questions over and over;
  • getting lost in familiar places;
  • not being able to follow directions;
  • confusion over time, people and places;
  • forgetting to eat right and regularly;
  • not bathing;
  • poor judgment about safety;
  • driving problems.

Medicines That Cause Forgetfulness

Forgetfulness is common among drug and alcohol abusers, but certain medicines also list forgetfulness as one of their side effects. Due to the age-related medical conditions, elderly people are more affected by the negative side effects, caused by medications. Approximately 163,000 people in the United States are estimated to experience serious cognitive impairment either caused or worsened by drugs.

For example, a beta-blocker medication, such as Inderal, generic name propranolol, or Lopressor, generic name metoprolol, may cause short-term memory problems. Similar results have been reported in patients who use such medications which contain the active ingredient methyldopa. Additionally, many antidepressants cause memory-related problems, especially in the beginning of the treatment. The same applies to anti-anxiety medicines like lorazepam and alprazolam or sleeping pills like triazolam. Benzodiazepines that are used to treat such disorders as anxiety, restless legs and social phobias seem to cause forgetfulness. Tranquilizers that are used to treat such conditions as Tourette syndrome and irritable bowel syndrome also seem to cause forgetfulness in some patients. Some drugs aimed at reducing high levels of cholesterol have also been criticized for such side effects. Even over-the-counter medicines, such as the antihistamine diphenhydramine, have been linked to forgetfulness.

Image and video hosting by TinyPic

The Boundaries between Dementia and “Normal” Ageing

As a general rule, the lower the score on cognitive tests, the more likely it is that the person has dementia. However, Storandt & Hill (1989) found that scores of patients with very mild Alzheimer’s overlapped considerably with those of both normal older people and people with mild Alzheimer’s. Furthermore, even where people do show some degree of memory impairment, progression to dementia is not inevitable.

The area of uncertainty between “normal” ageing and dementia has attracted a number of attempts to define diagnostic categories. Among the diagnostic labels suggested are age-associated memory impairment (AAMI), mild cognitive impairment, benign senescent forgetfulness, and minimal or questionable dementia. These concepts remain controversial, and practice varies regarding their use. The category of AAMI, for example, would include large numbers of older people, and it is questionable whether changes that are essentially normative should be labeled in this way.

Which Tests Are Useful in Discriminating between Dementia and Normal Ageing?

The CERAD studies suggest that the best discriminator is performance on delayed recall tasks. A 10-word list presented in three learning trials and tested after a 5–8 min delay correctly classified 94% of controls and 86% of patients with mild dementia, using a cutting score of 2 SDs below the control group mean. Performance on naming tests was found to be useful as an adjunctive measure. If patients have impairment in delayed recall and problems in naming or verbal fluency, this is a very strong indicator for dementia. Other studies have also emphasized the value of delayed recall. Tierney et al. (1996) found that problems in delayed recall and attention were the best predictors of whether people with mild memory problems would go on to develop Alzheimer’s disease.


Sources and Additional Information:
The Book of Memory Disorders by Alan D. Baddeley


Related Posts Plugin for WordPress, Blogger...