Friday, September 1, 2023

Ancient History of Dementia Research

 

Etymology of Dementia

The word "dementia" has its origins in Latin and can be traced back to ancient Roman medical texts. Perhaps the earliest record of a dementia syndrome originated in ancient Egypt in about 3,000 BC, when Prince Ptah-Hotep mentioned senile deterioration, which for the time was a consequential natural landmark in the process of human aging. But the world dementia appeared first in the record of mankind in around 600 A.D. Saint Isidore (560–636 A.D.), the archbishop of Seville, used the term ‘dementia’ for the first time in his book, ‘Etymologies’. The term "dementia" is derived from the Latin words "de" and "mentia."

1.       "De": In Latin, "de" is a prefix that is often used to indicate a negative or reversal of a condition. In this context, it suggests a loss or deprivation of something.

2.       "Mentia": "Mentia" is derived from the Latin word "mens," which means "mind" or "intellect." Therefore, "mentia" implies a condition related to the mind or intellect.

When combined, "dementia" essentially means a state of mind characterized by a loss or deprivation of mental abilities or intellect. It was originally used in Latin to describe a condition in which a person's cognitive and intellectual faculties were impaired or diminished.

The term "dementia" has been used for centuries to describe a range of cognitive disorders and conditions involving memory loss, confusion, and impaired thinking. It continues to be a fundamental concept in the field of neurology and psychiatry, where it is used to classify and diagnose various disorders, including Alzheimer's disease, vascular dementia, and other forms of cognitive impairment.

Ancient History of Dementia

Dementia has occurred in human history long before it was named. In about 3000 B.C., the ancient Egyptians were already aware that memory declines as people age.

Pythagoras (570–495 B.C.), a doctor and mathematician in Greece, classified a lifetime of human into six stages; infancy (age 0–6), adolescence (age 7–21), adulthood (age 22–49), middle age (age 50–62), senescence (age 63–79), and old age (age 80 or older). Of these stages, senescence and old age were regarded as a declining phase of mind and body, and some people who survive to this time, were expected to degenerate in mind to a level of suckling baby and finally become stupid. Hippocrates (460–370 B.C.), a doctor in Greece, believed that brain injury results in cognitive disorder, and Plato (428–347 B.C.), a philosopher in Greece, mentioned that the principal cause of dementia is old age itself because the mental performance is destined to inevitably degrade. The Greek physician Hippocrates (circa 460-370 BCE) mentioned cognitive decline in older individuals, referring to it as "senile debility." The ancient Greeks recognized that aging could bring cognitive and physical changes. On the contrary, Marcus Tullius Cicero (106–43 B.C.), a philosopher, politician and jurist in Rome, pointed out that ageing does not always cause the decline of mental performance, except in people with weak will. In brief, he indicated that dementia is not an inevitable consequence of ageing.

Around the 2nd century A.D., Aretheus, a doctor in Turkey, described dementia by grouping it respectively into delirium, a reversible acute disorder of cognitive function and dementia, an irreversible chronic disorder.

 in the 2nd century, Galenus wrote about cognitive decline in old age and also expanded on the humours theory. At the time, they believed dementia was a result of someone taking too much black bile.

A Roman philosopher and statesman, Cicero encouraged people to fight senility by engaging with intellectual activity. This is still encouraged to date.

Celsus, a Roman encyclopedist, was the first person to make the correlation between ageing symptoms and dementia. He used the term ‘dementatus’ to describe the condition showing symptoms of dementia. The term is derived from the Latin word ‘demens,’ meaning ‘out of your mind’ or ‘mad.’


Treatment

In the ancient world, the understanding of dementia and its treatment was quite limited compared to modern medicine. Dementia-like symptoms were often attributed to supernatural or mystical causes, and treatment approaches were often based on superstition, religious beliefs, or unscientific practices. Here are some historical methods and beliefs regarding the treatment of dementia-like conditions in the ancient world:

1.       Magical and Mystical Beliefs: Many ancient cultures believed that dementia-like symptoms were caused by curses, evil spirits, or supernatural forces. Consequently, treatment often involved rituals, exorcisms, or magical incantations to ward off malevolent influences.

2.       Herbal Remedies: Some ancient civilizations, such as the Greeks and Egyptians, had knowledge of herbal medicine. Certain plants and herbs were believed to have medicinal properties and were used to treat various ailments, including cognitive difficulties. However, the effectiveness of these remedies in treating dementia-like conditions was limited. Here are a few examples of herbs and substances that were historically used in ancient cultures:

·         Ginkgo Biloba: Ginkgo biloba is one of the oldest tree species on Earth, and its leaves have been used in traditional Chinese medicine for centuries. Some ancient Chinese texts mention ginkgo as a remedy for memory-related issues and cognitive problems. In modern times, ginkgo extract is still sometimes considered for its potential cognitive benefits, although scientific evidence is mixed.

·         Gotu Kola (Centella asiatica): Gotu kola is an herb traditionally used in Ayurvedic and traditional Chinese medicine. It has been suggested to have cognitive-enhancing properties. In Ayurveda, it is sometimes referred to as a "brain tonic."

·         Bacopa Monnieri: Bacopa monnieri, also known as Brahmi in Ayurvedic medicine, has a long history of use for memory enhancement and cognitive support in India. It's often included in Ayurvedic formulations aimed at improving mental clarity and cognitive function.

·         Turmeric (Curcuma longa): Turmeric is a spice used in traditional Indian cuisine and Ayurvedic medicine. It contains curcumin, a compound that has been studied for its potential neuroprotective properties and anti-inflammatory effects. While not a direct treatment for dementia, turmeric has been researched for its potential role in brain health.

·         Ginseng: Ginseng is an herb used in traditional Chinese medicine and other traditional systems. It has been suggested to have adaptogenic properties that may support overall well-being, including cognitive function.

·         Sage (Salvia officinalis): Sage has a history of use in traditional European herbal medicine for cognitive enhancement and memory support. Some ancient texts mention its potential benefits for mental clarity.

·         Rosemary (Rosmarinus officinalis): Rosemary has been used in traditional herbal medicine for its potential cognitive-enhancing properties. In some cultures, it was believed to improve memory and concentration.

3.       Bathing and Hydrotherapy: Water was sometimes used as a therapeutic intervention. Ancient Roman and Greek bathhouses were considered places of healing, and individuals with cognitive impairments might be immersed in water in the hope of improving their mental state.

4.       Dietary Changes: Dietary modifications were sometimes recommended. Certain foods were believed to have medicinal properties, and it was thought that adjusting one's diet could improve mental health. However, these dietary changes were often based on cultural or anecdotal beliefs rather than scientific evidence.

5.       Physical Restraints: In some cases, individuals with dementia or severe mental illness were physically restrained or confined to prevent them from harming themselves or others. These practices were often inhumane and lacked a scientific understanding of mental health.

6.       Religious and Spiritual Practices: In societies with strong religious beliefs, prayer, meditation, and participation in religious rituals were common approaches to addressing cognitive and behavioral issues. Individuals and their families might seek divine intervention to alleviate symptoms.

7.       Home Care and Family Support: In many ancient cultures, individuals with cognitive impairments were cared for within the family. Families often took on the responsibility of looking after affected members, providing emotional support, and attempting various home remedies.

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